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KMID : 0369819910210020085
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Jorunal of Korean Pharmaceutical Sciences
1991 Volume.21 No. 2 p.85 ~ p.90
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Biopharmaceutical Studies of 1 , 2 - Ethanediolester and 1 , 4 - Butanediolester of Flurbiprofen
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노재일/Rho JI
이완하/Lee WH
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Abstract
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Prodrugs of flurbiprofen, 1,2-ethanediolester(FE) and 1,4-butanediolester(FB) were prepared and their biopharmaceutical studies were performed. The prodrugs showed high stability in simulated gastric fluid, simulated intestinal fluid and pancreatin-saturated solution. Pharmacokinetic parameters of the prodrugs were similar to those of their parent drug. However they showed less acute toxicity and gastric irritation and higher anti-inflammatory and analgesic effects.
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KEYWORD
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prodrug, flurbiprofen, biopharmaceutical studies, pharmacokinetic parameters, acute toxicity, gastric irritation, anti-inflammatory and analgesic effects
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FullTexts / Linksout information
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